Transfer RNA modification: influence on translational frameshifting and metabolism
نویسندگان
چکیده
منابع مشابه
Depletion of cognate charged transfer RNA causes translational frameshifting within the expanded CAG stretch in huntingtin.
Huntington disease (HD), a dominantly inherited neurodegenerative disorder caused by the expansion of a CAG-encoded polyglutamine (polyQ) repeat in huntingtin (Htt), displays a highly heterogeneous etiopathology and disease onset. Here, we show that the translation of expanded CAG repeats in mutant Htt exon 1 leads to a depletion of charged glutaminyl-transfer RNA (tRNA)(Gln-CUG) that pairs exc...
متن کاملProgrammed translational frameshifting.
Errors that alter the reading frame occur extremely rarely during translation, yet some genes have evolved sequences that efficiently induce frameshifting. These sequences, termed programmed frameshift sites, manipulate the translational apparatus to promote non-canonical decoding. Frameshifts are mechanistically diverse. Most cause a -1 shift of frames; the first such site was discovered in a ...
متن کاملSummary of symposium on transfer RNA and transfer RNA modification in differentiation and neoplasia.
isomorphous replacements, for clarification and possible decision among the several structures proposed. tRNA has long been known to be rich in minor base modifications (6, 20), of which the most common is methylation, and this occurs on all 4 major bases. Data presented at this symposium by Stulberg and Shugart (72) support the logical inference that these base modifications change the tertiar...
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Spontaneous changes in the reading frame of translation are rare (frequencyof 10 to 10 per codon), but canbe inducedby specific features in the messenger RNA (mRNA). In the presence of mRNA secondary structures, a heptanucleotide ‘slippery sequence’ usually defined by the motif X XXY YYZ, and (in some prokaryotic cases) mRNA sequences that base pair with the 39 end of the 16S ribosomal rRNA (in...
متن کاملIron-related modification of bacterial transfer RNA.
Transfer RNAs isolated from E. coli grown in media where ferric iron is not freely available show well characterized chromatographic changes due to the absence of the methylthio moiety of ms2i6A. The altered tRNA molecules include tRNA trp tRNA tyr, tRNA phe and two minor tRNA ser species. It has been suggested that methylthiolation of tRNA affects its function in regulation. We now show iron-r...
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ژورنال
عنوان ژورنال: FEBS Letters
سال: 1999
ISSN: 0014-5793
DOI: 10.1016/s0014-5793(99)00528-1